AKT1 and Anxiety: In order to investigate the potential molecular mechanism of the reduction in anxiety- and antidepressive-like-related behavior of +/+ MIA-602 and −/− control animals, we studied the serine/threonine kinase (AKT), phosphorylated AKT (P-AKT), and phosphoinositide 3-kinase (PI3K) protein levels in the prefrontal cortex.