TP53 and pancreatic ductal adenocarcinoma: First, we included our recently published single-cell RNA-sequencing (scRNA-seq) datasets [10,11] to compare two mouse models with autochthonous pancreatic ductal adenocarcinoma (PDAC): the KPmut (KrasG12D; Trp53R172H) mouse model with KRASG12D mutation and p53R172H mutation, as compared to the KPloss (KrasG12D; Trp53cKO) mouse model with KRASG12D mutation and p53 loss (Figure 1A,B).