As an initial test of drug potential to treat sarcopenia, it may be preferable to utilize alternative and readily available genetic models of aging, such as the senescence-accelerated mouse P8 (SAMP8) or the Zmpste24−/− accelerated aging model of progeria syndrome, as described by Liu et al. and Guo et al. [147,203]. Here, ZMPSTE24 is linked to sarcopenia.