This group includes interferon-inducible protein 16 (IFI16), myeloid cell nuclear differentiation antigen (MNDA), absent in melanoma 2 (AIM2), and pyrin and HIN domain family member 1 (PYHIN1), each of which has been reported to be related to tumor progression [26,27,28,29]. The gene discussed is PYHIN1; the disease is neoplasm.