MAPT and Alzheimer disease: In line with this, prolonged hyperbaric oxygen treatment can reduce hypoxia, neuroinflammation, the accumulation of Aβ and phosphorylated tau, leading to a significant improvement of cognitive performances in a 3xTg AD mouse model carrying three mutations associated with familial AD (APP Swedish, MAPT P301L, and PSEN1 M146V) when tested in hippocampal-dependent behavioral tasks [214] and, possibly, in affected patients [215].