Moreover, the activation of PYrin (PYD)-Domain-containing protein 3 inflammasome (NLRP3) [145], which affects the microglial-dependent clearance of Aβ [146] and promotes tau pathology [147], is triggered in the brain as a consequence of SARS-CoV-2 neuroinvasion, just as described in the AD etiology. Here, MAPT is linked to Alzheimer disease.