MAPT and infection: In a similar way, hyperphosphorylation at the Ser262 and Ser396 sites and the mislocalization and increased aggregation of tau are also detected in human neuron-like SH-SY5Y cells after in vitro infection with different clinical strains (B.1, B.1.1.7 and B.1.617.2) of SARS-CoV-2 [200].