ACE2 and Alzheimer disease: In concomitance with an elevation in the mRNA transcript of ACE2 facilitating the entry points of SARS-CoV-2 in the CNS, a high level of its TBS/Detergent-soluble inactive form has also been detected in the parietal cortex of two large cohorts of AD-fully diagnosed subjects when compared to controls, suggesting that a defective brain RAS signaling with a consequent decrease in its anti-inflammatory and neuroprotective properties is more likely to take place in humans with a low cognitive score [115].