Finally, based on the evidence connecting the repeated infection of Herpex Simplex Virus type-1 (HSV-1) and amyloidosis, the viral re-activation of SARS-CoV-2 in the CNS in concomitance with an age-dependent physiological decline of innate immunity is more likely to trigger an inflammatory process which, in turn, increases the Aβ synthesis and accumulation, as well as the hyperphosphorylation of tau (pTau) and aggregation, a cascade that is suggestive of the so-called “infection hypotesis of AD” [68,111]. This evidence concerns the gene MAPT and Alzheimer disease.