MAPT and Alzheimer disease: More importantly, SARS-CoV-2 targets the neurons of 3D human brain organoids, inducing an aberrant subcellular redistribution of tau from axonal processes to soma, hyperphosphorylation at Threonine 231 (Thr231), apoptotic caspase-3 activation and, eventually, neuronal death, specific cellular changes that are reminiscent of key features associated with AD neuropathology [199].