AKT1 and acne: In fact, IGF-1 has been shown to induce SREBF1 expression and lipogenesis in SEB-1 sebocytes via the activation of the PI3K/AKT pathway [30], whereas a low glycemic diet, which decreases IGF-1 serum levels [12], reduces SREBF1 expression in the sebaceous glands (SGs) of acne patients [31] (Figure 1).