Another interesting study conducted by Shibata and colleagues found that pancreatic cancer-derived EVs carry adipocyte-targeting integrins, integrin subunit beta 1 (ITGB1) and integrin subunit alpha 6 (ITGA6), that aid in inducing lipolysis during pancreatic cancer-associated cachexia. Here, ITGA6 is linked to familial pancreatic carcinoma.