In other considerations with WISP1, the down-regulation of WISP1, either through the direct control of non-coding RNAs or through non-coding RNAs using AMPK, may be a potential therapeutic target to limit tumor growth [514], an important consideration for the trophic pathways of Wnt signaling and WISP1 that can promote tumorigenesis [76,130,337,457,461,462,470,515,516]. The gene discussed is CCN4; the disease is neoplasm.