Interestingly, lncRNA growth arrest-specific 5 (GAS5) functions as a tumor suppressor in glioma cells by alleviating the promoter methylation of miR-424, and consequently increasing the expression of miR-424, and suppressing AKT3 and its targets, cyclinD1, c-Myc, Bax, and Bcl-2 [99]. Here, CCND1 is linked to central nervous system cancer.