For example, AKT3 promotes the survival of 40–60% non-hereditary melanoma cells and the development of malignant melanoma [32]; in addition, it plays an important oncogenic role in triple negative breast cancer (TNBC), colorectal cancer (CRC), invasion and metastasis of glioma, and lung cancer [2,33,34]. This evidence concerns the gene AKT3 and colorectal carcinoma.