FAH and hepatocellular carcinoma: As described in Figure S1, at 100% concentration of NTBC (7.5 mg/L), the liver of Fah−/− mice was preserved normally; Fah−/− mice developed acute liver injury and died at 3−6 weeks without any NTBC; and at 2.5% concentration of NTBC (.2 mg/L), Fah−/− mice survived but suffered CLI and showed HCC after 12 weeks.