NLRP3 and familial Mediterranean fever: While it is known that colchicine can inhibit IL-1β release from peripheral blood mononuclear cells of FMF patients, the specific efficacy of colchicine in the treatment of FMF and the impact of disease-specific MEFV variants on the RhoA-induced pyrin inflammasome and NLRP3 inflammasomes are still unclear [7].