SIRT3 and renal cell carcinoma: Detailed Kaplan Meier univariate survival analysis of each type of RCC revealed that nucleocytoplasmic ARK5 expression and SIRT3 positivity have a significant negative impact on the survival of patients with clear RCC (P = 0.024 and 0.016) (Fig. 2) while they do not have any effect on the survival of patients with papillary RCC (P = 0.99 and 0.94) nor chromophobe RCC (P = 0.67 and 0.59).