SIRT3 and neoplasm: Furthermore, significant associations were found between H score of SIRT3 expression and tumour grade, apoptotic and mitotic index, tumour extent, tumour stage and tumour response to therapy (P = 0.037, 0.016, 0.002, 0.001, 0.001 and 0.037) where higher tumour grade, low apoptosis, higher cellular proliferation, larger tumour size, extension to renal vessels and perirenal fascia, advanced tumour stage and worse response to chemotherapy were associated with higher H score.