We did not identify an association between increased genetically proxied TIE1 signalling and liability to POAG (OR = 1.04 per SD increase in circulating sTIE1, 95% CI = 0.94 to 1.15, P = 0.479) (Fig. 4 and Additional file 7: Table S7). This evidence concerns the gene TIE1 and open-angle glaucoma.