CRP and polycystic ovary syndrome: Although there are conflicting reports regarding increased inflammatory markers such as C-reactive protein and alteration in the expression of inflammatory cytokines [e.g., upregulation of interleukin (IL) 6, IL8, IL1β, and TNFα] in granulosa cells in PCOS [83–88], there is evidence they may result in a premature influx of leukocytes, specifically through macrophage activation.