INS and polycystic ovary syndrome: To support these assertions, metformin and troglitazone used in PCOS (an agonist of the peroxisome-proliferator-activated receptor gamma), with insulin sensitizing abilities in adipocytes have been shown to exert potent anti-inflammatory effects in macrophages [81, 82] that not only improve insulin sensitivity but also reduces inflammation, measured as C-reactive protein levels [89].