DDAH1 and polycystic ovary syndrome: Using Dehydroepiandrosterone (DHEA)-induced PCOS Sprague Dawley rats and the ovarian granulosa cell line KGN, Li and colleagues [115] investigated the effect of the ADMA-dimethylarginine dimethylaminohydrolase 1 (DDAH1) pathway on redox status and ovarian apoptosis.