In imatinib-resistant gastrointestinal stromal tumors, ETV1 activates METTL3 transcription and further promotes m6A modification mediated by METTL3 at the 5’UTR of MRP1 RNA, stimulating translation of MRP1 RNA and promoting imatinib resistance in tumor cells [112]. The gene discussed is METTL3; the disease is neoplasm.