CD274 and neoplasm: Most tumors shape the tumor microenvironment to promote tumor immune escape by recruiting immunosuppressive cells such as myeloid-derived suppressor cells (MDSCs), regulatory T cells (Tregs) and tumor-associated macrophages (TAMs), or by activating immunosuppressive signaling pathways such as those involving PD1/PDL1.It has been found that METTL3 plays an important role in tumor immune escape (Fig. 6).