MUC5AC and pancreatic intraductal papillary-mucinous neoplasm: Moreover, we calculated the gene set activity for the Mucin O-glycosylation pathway (R-HSA-913709) using the AddModuleScore function and we found a consistent activation of this pathway in HG IPMNs in respect to LG IPMNs (Fig. 1e) indicating that this process was intensively activated in the malignant IPMN.