Moreover we found, in line with previous studies [6], that low-grade IPMN where characterized by a high number of CD8+ T cells whereas the stroma of high-grade IPMN was characterized by the presence of CD68+ and CD163+ macrophages, and CD4+ T cells while CD8+ T cells were a minority (Fig. 2d and e). The gene discussed is CD4; the disease is pancreatic intraductal papillary-mucinous neoplasm.