As for the three indicators of triple-negative breast cancer (TNBC), the risk score was significantly higher in ER and PR-negative groups (Wilcoxon rank-sum test p-value < 2.2e-16, Fig. 4D, E), while it didn’t show a relationship with Her-2 status, probably due to the limited sample size of Her-2+ patients (Fig. 4F). Here, ESR1 is linked to triple-negative breast carcinoma.