As a splicing factor, TDP-43 can affect alternative splicing of various genes, such as apolipoprotein A-II [25], RXRG [26], SC35 [27], SMN [28], ETF1 [26], BRCA1 [26], schizophrenia-associated TNIK gene [29], PAR3/NUMB [30], and cancer stem cell marker CD44 [31]. This evidence concerns the gene TARDBP and cancer.