The top 10 antidiabetic agents with the highest hypoglycemia ROR (95% CI) were pramlintide 34.87 (31.60-38.48), insulin 30.73 (30.29-31.17), acarbose 26.83 (24.62-29.23), repaglinide 26.52 (25.01-28.13), chlorpropamide 23.47 (15.47-35.59), glyburide 22.27 (21.44-23.13), exenatide 19.47 (18.98-19.97), glimepiride 18.84 (18.28-19.43), tolazamide 16.42 (7.58-35.59), and lixisenatide 15.10 (12.81-17.81). This evidence concerns the gene INS and Hypoglycemia.