INS and Hypoglycemia: The top 10 antidiabetic agents with the highest number of hypoglycemia reports were insulin (35,811), metformin (16,610), exenatide (7,046), glimepiride (4,784), glipizide (3,386), glyburide (3,116), sitagliptin (2,900), pioglitazone (2,472), liraglutide (1,658), and dulaglutide (1,615).