After the involvement of the NLRP3 inflammasome in gout attacks was demonstrated, it was thought that only MSUc were responsible for the formation and activation of the NLRP3-ASC-caspase 1 protein complex, which performs proteolysis of pro-IL-1β to active IL-1β (Martinon et al. 2002). The gene discussed is IL1B; the disease is gout.