In understanding the neuroendocrine pathology of PCOS, the hypothalamus circuits that have received the most attention include the arcuate kisspeptin neurons recently identified as the GnRH neuron pulse generator [20, 21] and GABAergic neurons [21], there are various upstream neural and endocrine factors that contribute to both the timing and magnitude of GnRH secretion, with the stimulation of GnRH neurons by GABA occurring through the GABA receptor [20]. Here, GNRH1 is linked to polycystic ovary syndrome.