PLOD1 and polycystic ovary syndrome: A disruption of this axis in women with PCOS leads to abnormal levels of hormones such as the luteinizing hormone (LH), follicle stimulating hormone (FSH), and androgens, resulting in irregular periods, infertility, polycystic ovaries, hirsutism, acne and metabolic problems, with obesity and insulin resistance (IR) among the main factors influencing the clinical manifestations of PCOS.