YAP1 and idiopathic pulmonary fibrosis: However, overexpression of YAP/TAZ has been shown to enhance the epithelial-mesenchymal transition in cancer (Chen et al. 2016; Yuan et al. 2016), and increased epithelial YAP activity has been reported in the lungs of patients with idiopathic pulmonary fibrosis (IPF) (Gokey et al. 2018).