This upregulation of nuclear DCLK1 in the early phase of AECII cell injury may activate the downstream signaling pathways, promoting proinflammatory cytokine production in response to virus infection (Undi et al. 2022) and causing neutrophil activation in LPS-induced murine colitis to eliminate microbial invasion (Roy et al. 2021). The gene discussed is DCLK1; the disease is viral infectious disease.