Of note, tumor protein P53 (TP53) mutation status also trended with YC-enriched cancers, with mutation-bearing tumors representing 48%, 25% and 20% of YC-enriched, YC-neutral and YC-depleted tumors, respectively (chi-squared test, P = 0.42) (Fig. 2b and Supplementary Table 2). The gene discussed is TP53; the disease is cancer.