CLCN3 and cancer: This revealed that mutations in KIAA0586, CLCN3, ZNF22, MRPS16, DLEU7, TBX2, MKKS, DVL1 and ADGRG7 were all significantly associated with YC-depleted cancers, while USH2A mutations were significantly associated with YC-enriched cancers (Supplementary Table 3).