KCNN4 and central nervous system cancer: Since TGF-β has also been reported to exert several immuno-suppressive functions41 and KCa3.1 has been proposed to exert pivotal functions in the anti-cancer immune response31,32 or T cell migration27 on its own, we next analyzed the effects of fractionated irradiation and KCa3.1 targeting on the immune microenvironment of the SMA-560 glioma mouse model.