Of the 466 melanoma patients in TCGA, 46 (10%) carried somatic mutations in PTPRC, and patients with PTPRC mutations had a significantly higher TMB than wild-type samples (Supplementary material Fig S2i, P < 0.001), and the high-PTPRC group had a higher TMB (Supplementary material Fig S2h, P = 0.029). Here, PTPRC is linked to melanoma.