Using Id1f/f and Id1Lyz-KO mice, we demonstrated that depletion of Id1 in myeloid cells largely but not totally reversed the tumor inhibitory role of ML323 in MC38 s.c. model (Fig. 7j, k; Supplementary Fig. 6h), indicating that ML323 works partly through Id1 in myeloid cells. This evidence concerns the gene ID1 and neoplasm.