SHH and neoplasm: Gene set enrichment analysis (GSEA) suggested that Id1 deletion in TAMs resulted in the inhibition of focal adhesion kinase (FAK) and Yes-associated protein (YAP) signaling pathways but not other tumor stemness associated signaling such as Notch, Wnt/β-catenin and Sonic hedgehog (SHH) pathway (Fig. 4h, i; Supplementary Fig. 3i)29,30.