From the immune response regulation aspect, 20 upregulated genes encoding chemokines with log2FC > 1.5 were selected, among which Ccl3, Ccl4, Cxcl9 and Cxcl16 shared with both tumor suppressive roles and effects in promotion of T cell infiltration (Fig. 5c)33–36. This evidence concerns the gene CCL4 and neoplasm.