Previous studies including ours demonstrate that CXCR4 signaling contributes to prostate cancer cell colonization to bone tumor microenvironment and interact with osteoblastic niche for establishment of PC bone metastasis, herein, our data also demonstrate that PI4KIIIα knockdown significantly inhibited bone tumor growth suggesting CXCR4 downstream signaling through PI4KIIIα activation in PCa cells contributes to bone tumor growth. The gene discussed is CXCR4; the disease is pachyonychia congenita.