In this regard, we determined the novel downstream interactors of CXCR4 in PCa cells, using SILAC proteomic analysis, and found phosphatidylinositol kinase PI4KIIIα enriched in CXCR4 expressing PC cells in addition to expected G-protein coupled receptor signaling components21. Here, CXCR4 is linked to pachyonychia congenita.