MYB and leukemia: As we have previously demonstrated that MYB manipulation in different leukaemia phenotypes can override the differentiation block to instruct a myeloid commitment programme, we performed flow cytometric analysis to test the cell differentiation capacity by measuring CD11b and CD14 surface markers, observing a shift in the expression of myeloid markers in MOLM14 and KASUMI1, but not in FUJIOKA cells, suggesting a lower extent of MYB expression dependency in leukaemias with complex karyotype (Fig. 1C).