Recently, we discovered the protective function of myeloid SIRT1 [14, 15] and its negative regulation of canonical inflammasome-pyroptosis in human and murine OLT [16], while others have shown that hepatocyte SIRT1 deficiency impaired lipid homeostasis and promoted steatosis in mouse livers under high-fat diet [17]. This evidence concerns the gene SIRT1 and steatosis.