(I) Comparisons between non TSC control samples (nmax = 52) and TSC samples (nmax = 126) without prior treatment and no seizure history, of any age (including samples from individuals that showed abnormal EEGs at sample draw) identified 39 significant associations: three protein groups (catalase, collagen alpha-2(I), Peroxiredoxin-2), and two metabolites (aminoimidazole carboxamide ribonucleotide, leucine-isoleucine), all five higher in TSC c/w control; and 34 RNAs (25 higher in TSC subjects) (FDR < 0.05, fold change > 1.5, Supplementary Data 5, Supplementary Fig. 8). The gene discussed is CAT; the disease is tuberous sclerosis.