Slc35d3 was expressed at lower levels in the fat tissues of obese mice, and Slc35d3 knockout induced more beige-to-white transition of IngWAT and showed more susceptibility to obesity, impaired glucose tolerance and exacerbated chronic inflammation, while Slc35d3 knock-in promoted browning of WAT and was protected against obesity. The gene discussed is SLC35D3; the disease is obesity disorder.