IL6 and schizophrenia: There is now evidence that schizophrenia, and particularly its more severe phenotype deficit schizophrenia, is a neuro-immune and neuro-oxidative disorder [29–31], with elevated levels of pro-inflammatory cytokines such as IL-1β, IL-6, IL-12p70, and TNF-α [32, 33], activation of macrophage M1, Th-1, Th-2, Th-17, and T regulatory (Treg) phenotypes, as well as activation of the immune-inflammatory response system (IRS) and the compensatory immune-regulatory systems (CIRS), which tend to downregulate the IRS and prevent hyperinflammation [31].