LYZ and bacterial infectious disease: Accordingly, the as-designed MSNs-based therapeutic system achieved effective chemotherapy-gene therapy to overcome the multidrug resistance in breast cancer.478 Besides, drug-resistant bacterial infections are a current thorny public health issue.479 In this regard, researchers have developed a photodynamic combined lysozyme antimicrobial therapy based on upconversion NPs/MSNs nanocomposites to combat the problem of drug-resistant bacterial infections in deep tissues.