STX6 and prion disease: However considering syntaxin-6 itself has been proposed as a particularly promiscuous SNARE protein with a multitude of cell-type specific functions, we cannot discount that the pathological role of syntaxin-6 is mediated through non-neuronal cell types, fitting with the increasing acceptance that prion disease pathobiology is driven by the interaction of multiple cell types and non-cell autonomous mechanisms (Tahir et al., 2020; Smith et al., 2020).