STX6 and early-onset autosomal dominant Alzheimer disease: Interestingly the STX6 locus has also been implicated in other neurodegenerative diseases, with the same genetic variants being associated with progressive supranuclear palsy (PSP) (Höglinger et al., 2011; Ferrari et al., 2014) and increased syntaxin-6 protein expression being causally associated with Alzheimer’s disease (AD) (Wingo et al., 2021; Yu et al., 2021), indicating this protein may play a pleiotropic role in neurodegeneration.