For this purpose, we employed stable isotope methods to quantify hepatic glucose and glycogen fluxes in mice with either intact or attenuated hepatic ChREBP signaling, in which intrahepatic G6P levels were acutely increased by short-term infusion of the chlorogenic acid S4048, a pharmacological inhibitor of the G6P transporter SLC37A4 [26], which is deficient in GSD Ib patients. This evidence concerns the gene MLXIPL and glycogen storage disease Ib.