CXCL10 levels were higher in SSc without ILD patients [Median (IQR): 78.5 pg/ml (50–122)] compared to healthy controls [4 pg/ml (4–9.1), P < 0.0001, 95% CI: 3.3 × 10−9 to 7.9 × 10−9] and between patients with SSc-ILD and healthy controls [126 pg/ml (66–282.5), P < 0.0001, 95% CI: 6.4 × 10−8 to 7.2 × 10−8]. This evidence concerns the gene CXCL10 and systemic sclerosis.