Lastly, it was observed that at 7 d (first peak of coccidiosis cycling; P = 0.05) and 14 d (after the C. perfringens challenge; P = 0.006) the supplementation of 35,000 LSU(F)/kg of feed of MUR significantly reduced the CD4+ lymphocyte infiltration in the liver to the same level as nonchallenged birds, while Enramycin only reduced it at d 7. The gene discussed is CD4; the disease is coccidiosis.