Since hypomethylation is the suggested mechanism behind the abnormal expression of the RIN3 gene in sepsis-induced ARDS [162] and SARS-CoV-2 is associated with Angiotensin-converting enzyme 2 (ACE2) hypomethylation [165], we may suggest a new genetic association between SARS-CoV-2 induced sepsis and AD. Here, RIN3 is linked to Alzheimer disease.