PICALM and Alzheimer disease: Several newly discovered genes, such as Sortilin-related receptor 1 (SORL1), Protein tyrosine kinase 2 beta (PTK2B), Myocyte Enhancer Factor 2C (MEF2C), Bridging integrator1 (BIN1), Phosphatidylinositol Binding Clathrin Assembly Protein (PICALM), and Ras and Rab Interactor 3 (RIN3), are implicated in cellular processes like endocytic trafficking, underscoring the role of these pathways in AD pathogenesis [12].