For example, ectopic expression of Snail in haematopoietic cells was found to predispose mice to acute myeloid leukaemia by interacting with the histone demethylase KDM1A/LSD1 [39], this is particularly important given the current interest in the use of LSD1 inhibitors for the treatment of many different malignancies, including AML. This evidence concerns the gene KDM1A and acute myeloid leukemia.