In contrast, a number of reported tumour suppressors were found in genes negatively associated with ALOX5AP expression, including negative regulators of EMT, such as ARHGAP29, RBM47 and KLF4; There's also the Wnt antagonist gene DKK2 in the mix, it has been proposed that overexpression of KIF4 may inhibit EMT in gastric cancer cells through the Wnt/β-catenin signalling pathway[21]. The gene discussed is KLF4; the disease is gastric cancer.