In recent years, only one study has reported that ALOX5AP gene locus polymorphism may be associated with susceptibility to acute myeloid leukemia [10] via polymerase chain reaction-restriction fragment length polymorphism (PCR–RFLP) combined with directly sequencing, and there are currently no reports on the correlation between expression and methylation levels. Here, ALOX5AP is linked to acute myeloid leukemia.