ZEB1 and leukemia: Furthermore, ZEB2 is a classical EMT regulator that has been shown to play an important role in haematopoiesis and leukaemia transformation [40], Wang et al. demonstrated the oncogenic role of ZEB1/2 in AML by showing that inactivation of ZEB2 alone or ZEB1/2 together improves survival in the secondary MLL-AF9 acute myeloid leukaemia (AML) model [41], indicating the cellular environment dependence of EMT regulators.