SNAI1 and acute myeloid leukemia: For example, ectopic expression of Snail in haematopoietic cells was found to predispose mice to acute myeloid leukaemia by interacting with the histone demethylase KDM1A/LSD1 [39], this is particularly important given the current interest in the use of LSD1 inhibitors for the treatment of many different malignancies, including AML.