Among FAB subtypes, ALOX5AP expression in M4 and M5 was significantly higher than that in other subtypes, acute monoblastic/monocytic leukemia (AMoL), previously defined as M5 according to FAB classification, is one of the most common subtypes of AML in children, representing ~ 15–24% of all pediatric AMLs, new diagnostic markers need to be developed to obtain a clear distinction between leukemia and reactive monocytes [34]. Here, ALOX5AP is linked to acute monocytic leukemia.