Several studies have also reported that compounds with 5-HT7 antagonist properties were associated potential pro-cognitive effects, such as reversing natural forgetting impairment in rats (Canale et al., 2017; Pytka et al., 2017a) and reversing drug-induced memory impairments (Canale et al., 2016b; Jankowska et al., 2020; Zajdel et al., 2015). This evidence concerns the gene HTR7 and memory impairment.