Furthermore, 19 studies using agents with selective 5-HT7 antagonist properties found significant improvements in potential markers of depression; for example, SB-269970 was found to decrease animals’ immobility time both in water (FST) and land (TST) (Bonaventure et al., 2012, 2007; Canale et al., 2015, 2016b, 2016a, 2017; Guscott et al., 2005; Hedlund et al., 2005; Kim et al., 2016; Kucwaj-Brysz et al., 2018; Lax et al., 2018; Medina et al., 2014; Partyka et al., 2019; Stroth and Svenningsson, 2015; Wesolowska et al., 2006a, 2006b, 2007; Zajdel et al., 2011, 2015). This evidence concerns the gene HTR7 and depressive symptom measurement.