Benefiting from the scalability of VLP, studies have shown that incorporating additional immunological proteins adjuvants such as nucleoprotein (NP), Escherichia coli heat-labile enterotoxin B subunit protein (LTB), and flagellin into influenza VLP induces better cross-protection against heterologous H5N1 challenges than VLP alone [19,20]. The gene discussed is LTB; the disease is influenza.