SLC12A1 and chromophobe renal cell carcinoma: To identify candidate markers exclusively expressed in the other HOT population, we compared the RNAseq data of 1 HOT case and 90 chRCC cases and nominated genes highly expressed in HOT, but low in chRCC, including L1CAM, UMOD, SLC12A1, SALL1, and TMPRSS4 (Figure 1A).