To identify candidate markers exclusively expressed in the other HOT population, we compared the RNAseq data of 1 HOT case and 90 chRCC cases and nominated genes highly expressed in HOT, but low in chRCC, including L1CAM, UMOD, SLC12A1, SALL1, and TMPRSS4 (Figure 1A). This evidence concerns the gene TMPRSS4 and chromophobe renal cell carcinoma.