By combining IHC/RNA-ISH staining technology with hematoxylin and eosin staining (Figure 3), we confirmed the morphologic association of the two biomarkers: the strong membranous L1CAM expression was observed in HOT tumor cells with clear cytoplasm (with a previously reported resemblance to chRCC) (Figure 3B), whereas the nuclear LINC01187 expression was observed in HOT tumor cells with eosinophilic cytoplasm (with a previously reported resemblance to RO) (Figure 3C). Here, L1CAM is linked to neoplasm.