IFN-α2 is currently the most widely used interferon in clinical practice, including for the treatment of chronic hepatitis B. According to our previous research and reports from others, among all 13 known human IFN-α subtypes, IFN-α14 has shown very strong antiviral effects against HIV, HBV and SARS-CoV-2 when compared to other subtypes [6, 12, 15]. The gene discussed is IFNA14; the disease is chronic hepatitis B virus infection.