MiR‐375 and miR‐455 were identified to repress TRPV1 expression via targeting the 3’‐UTR of TRPV1 mRNA, which has been shown to be downregulated in patients with low back pain with neuropathic pain,201 so they may also function as therapeutic targets to indirectly modulate TRPV1 activity in arthritis. The gene discussed is TRPV1; the disease is arthritic joint disease.