TAMs, like CAFs, release a wide range of soluble factors in the TME, including chemokines, enzymes, interleukins, exosomes, and so forth, to combat drug attacks, for instance, TAMs can prevent paclitaxel‐induced tumor cell death by expressing cathepsin S and B.112Moreover, through overexpressed cytidine deaminase or CDA (an enzyme that is involved in gemcitabine degradation), TAMs can promote chemotherapy resistance in cancer.165, 192. The gene discussed is CDA; the disease is neoplasm.