TGFB1 and neoplasm: Primary tumor cells release exosomal miRNAs such as miR‐21, miR‐155, miR‐210, miR‐1247‐30, and miR‐124 that are transferred to normal fibroblasts (NFs), then, by targeting proteins such as SPHK1, PTEN, and SOCS1, as well as activating molecules such as FGF‐2, FAP, TGF‐β, and bFGF induce NFs conversion into CAFs, ultimately, ECM undergoes reshaping5, 36 Figure 2.