Dong and his colleagues in the year 2004 have found that ZNF165 mRNA is expressed in tumors of various tissue, which was confirmed by RT–PCR, real-time PCR, and Northern blotting analysis in which its gene expression was found in hepatocellular carcinoma, gastric cancer, colon cancer, and non-small-cell lung carcinoma [84]. This evidence concerns the gene ZNF165 and colonic neoplasm.