Thegene–gene interaction network constructed in this study shows ARMCX4 gene is co-expressed along with ZNF165 and STAT3 genes, which plays a vital role in developing colon cancer and inflammation in CD patients in which activation and mutation of the ARMCX4 gene along with other cancer driver and passenger cancer genes results in endometrial cancer. This evidence concerns the gene STAT3 and colonic neoplasm.