Additionally, using the NAFLD‐related HCC progression mouse model constructed based on the STAM mouse model,44 we observed a progressive increase in Hif1a expression during the disease progression of NAFLD, further confirming the upregulation of HIF1A expression in the development and advancement of NAFLD (Figure S4M). The gene discussed is HIF1A; the disease is metabolic dysfunction-associated steatotic liver disease.