HIF1A and hepatocellular carcinoma: In addition, the liver pathological microenvironment becomes progressively hypoxic during the progression of NAFLD‐related HCC, and hepatocytes adapt to the progressive hypoxia pathological microenvironment by upregulating HIF1A, which leads to changes in the metabolic level, proliferation potential, and pro‐angiogenic ability of hepatocytes, induced end‐stage liver disease.