E2F1 and neoplasm: By integrating logic-based network modeling and gene expression profiles of cancer cell lines from E2F1-driven tumors and patient cohorts displaying cancer aggressiveness, we identified tumor-type specific receptor signatures associated with EMT, where the combined action of highly expressed E2F1, TGFBR1, and FGFR1 triggers the most invasive phenotype [10, 14].