CASP3 and type 2 diabetes mellitus: Combined treatment with guava (Psidium guajava) and alginate was found to improve pancreatic β-cell function by decreasing caspase-3-mediated apoptosis, LC3-B-mediated cellular autophagy, and IL-1β-mediated cellular pyroptosis, which protects the kidneys and pancreas from the HG-induced damage of T2DM [15].