CRISPR/Cas9 mediated ARID3B KO in the xenografts (derived from CRC patients) revealed that ARID3B activated Notch target genes, ISC genes, and PD-L1 through recruiting lysine-specific demethylase 4 C (KDM4C) that modulates the chromatin configuration for transcriptional activation [101]. The gene discussed is ARID3B; the disease is colorectal carcinoma.